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目的探讨奥硝唑碘甘油糊剂治疗急性智齿冠周炎对冠周袋内菌群的影响及疗效。方法选择82例急性智齿冠周炎患者,随机分为观察组和对照组。两组患者均予以3%过氧化氢溶液和0.9%氯化钠注射液冲洗智齿冠周及盲袋。观察组冲洗后在智齿冠周及盲袋处涂奥硝唑碘甘油糊剂,每天换药1次,连用5 d,对照组采用相同的方法涂碘甘油糊剂,每天换药1次,连用5 d。5 d后观察两组的治疗效果及药物不良反应,同时在治疗前与治疗5 d后检测冠周袋内细菌,观察并比较两种治疗方式对患者冠周袋内细菌的影响。结果治疗5 d后,两组患齿冠周袋内细菌数值均较治疗前减少(P<0.05或P<0.01),且观察组减少的幅度明显大于对照组(P<0.01);观察组疼痛及冠周红肿好转及消失时间均短于对照组(P<0.05);治疗5 d后,观察组治疗有效率明显优于对照组(χ2=5.14,P<0.05);两组治疗期间均未出现明显药物不良反应。结论采用奥硝唑碘甘油糊剂治疗急性智齿冠周炎能有效的抑制患齿冠周袋内细菌的生长,患者疼痛及冠周红肿消退快,治疗效果佳,不良反应少。
Objective To investigate the effect of ornidazole iodine glycerin paste on perioclekin in the treatment of acute pericoronitis and its effect. Methods 82 patients with acute wisdom pericoronitis were randomly divided into observation group and control group. Two groups of patients were treated with 3% hydrogen peroxide solution and 0.9% sodium chloride injection flush wisdom crown perirenal and blind bags. Observation group rinse ornithine iodine glycerin paste in the pericardium and blind pocket at the rinsing of the observation group. The dressing was changed every day for 5 days. In the control group, iodoglycerin paste was applied in the same way and the dressing was changed every day. 5 d. Five days later, the curative effect and adverse drug reaction of the two groups were observed. The bacteria in the pericardium were detected before treatment and 5 days after treatment. The effects of the two treatment methods on the bacteria in the perianal crevicular pocket were observed and compared. Results After 5 days of treatment, the bacterial counts in the pericardium of the two groups were significantly lower than those before treatment (P <0.05 or P <0.01), and the extent of decrease in the observation group was significantly greater than that of the control group (P <0.01) (P <0.05). After 5 days of treatment, the effective rate of observation group was significantly better than that of control group (χ2 = 5.14, P <0.05); neither of the two groups had any improvement during the treatment period Obvious adverse drug reactions. Conclusion Ornidazole iodine glycerin paste for the treatment of acute wisdom tooth pericoronitis can effectively inhibit the growth of bacteria in the pericardial pocket of patients with pain and periapical redness subsided fast, the treatment effect is good, less adverse reactions.