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[目的]观察中西医结合治疗婴幼儿反复喘息的临床疗效。[方法]按诊断标准选取我院门诊、健康体检和住院病人已确诊反复喘息患儿150例,根据治疗方法的不同随机分为中西医结合治疗组(Ⅰ组)、中药治疗组(Ⅱ组)和西药治疗组(Ⅲ组),各50例。各组均给予抗生素抗感染等基础治疗,其中Ⅰ组给予酚妥拉明静注(0.5mg/kg～1.0mg/kg,2次/d)+布地奈德雾化吸入(200μg/次,2次/d)+和金汤口服(100mL,2次/d)的中西医结合治疗;Ⅱ组仅给予其和金汤口服的中药治疗(100mL,2次/d);Ⅲ组给予其酚妥拉明静注(0.5mg/kg～1.0mg/kg,2次/d)+布地奈德雾化吸入(200)ug/次,2次/d)的单纯西医治疗,观察三组在随访12周的临床症状、体征和X线检查表现、嗜酸性粒细胞计数、血浆免疫球蛋白IgE等实验室检查指标的变化。[结果]经对比,Ⅰ组临床症状、体征、X线检查表现、嗜酸性粒细胞计数、血浆免疫球蛋白IgE等实验室检查指标治疗前后改善情况显著优于其它两组,病程缓解天数最短;Ⅰ组治疗总有效率为92.00%,明显优于Ⅱ组的72.00%和Ⅲ组的70.00%。Ⅰ组临床疗效优于Ⅱ组和Ⅲ组。[结论]对反复喘息患儿采用中西医结合治疗,相比单纯西医或中医治疗更能行之有效的改善患儿临床症状和体征,值得临床推广。
[Objective] To observe the clinical efficacy of Integrative Chinese and Western medicine treatment of recurrent wheezing in infants and young children. [Methods] According to the diagnostic criteria, 150 cases of recurrent wheezing in our hospital, physical examinations and hospitalized patients were selected and randomly divided into two groups according to the different treatment methods: group Ⅰ (Ⅰ), group Ⅱ (TCM) And western medicine treatment group (group Ⅲ), 50 cases each. Each group was given antibiotics such as anti-infective and other basic treatment, in which Ⅰ group were given intravenous injection of phentolamine (0.5mg / kg ~ 1.0mg / kg, 2 times / d) budesonide inhalation (200μg / (100mL, 2 times / d); group Ⅱ was only treated with traditional Chinese medicine (100mL, twice daily), while group Ⅲ was given phentolamine Western medicine treatment of intravenous injection (0.5mg / kg ~ 1.0mg / kg, 2 times / d) + budesonide inhalation of atomization (200) ug / times, 2 times / d) Clinical symptoms, signs and X-ray examination performance, eosinophil count, plasma IgE and other laboratory tests index changes. [Result] Compared with the other two groups, the clinical symptoms, signs, X - ray examination, eosinophil count, IgE and other laboratory indexes in group Ⅰ were significantly better than the other two groups with the shortest number of days of remission; The total effective rate of group Ⅰ was 92.00%, which was significantly better than that of group Ⅱ 72.00% and group Ⅲ 70.00%. The clinical efficacy of group Ⅰ was better than that of group Ⅱ and Ⅲ. [Conclusion] Integrative treatment of children with recurrent wheezing, compared with simple Western medicine or Chinese medicine treatment is more effective in improving the clinical symptoms and signs in children worthy of clinical promotion.