目的：提高难溶药物呋塞米（ＦＤ）的溶出度。方法：筛选ＰＶＰ、玉米淀粉作载体，以磷酸氢二钠－枸橼酸缓冲系统来控制微环境ｐＨ值，用溶剂沉降法将ＦＤ制成固态分散体，进而制成胶囊剂。结果：Ｘ射线衍射实验表明，此固态分散体中ＦＤ为无定型、无结晶。其胶囊剂与普通片剂比较，溶出度显著提高。结论：将ＦＤ制成固态分散体可增加其溶出度 Objective: To improve the dissolution of insoluble drug furosemide (FD). Methods: PVP and corn starch were selected as carriers, and pH value of microenvironment was controlled by disodium hydrogen phosphate-niobic acid buffer system. FD was made into solid dispersion by solvent sedimentation and then made into capsules. Results: X-ray diffraction experiments showed that the FD in this solid dispersion was amorphous and crystal-free. Compared with ordinary tablets, the dissolution rate of the capsules is significantly increased. Conclusion: FD can be made into solid dispersion to increase its dissolution