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目的使用心脏超声对鸡胚心脏左心室射血分数(LVEF)测定来评估扩张型心肌病心力衰竭患者是否存在心肌自身抑制性抗体。方法按随机数表法选取36例扩张型心肌病心力衰竭患者和23例冠心病心力衰竭患者的IgG血清,滴入18 d胚龄的鸡胚中,用超声心动图仪检测鸡胚心肌抑制状况。结果冠心病心力衰竭组LVEF为81.03%±2.67%,扩张型心肌病心力衰竭组中,心肌自身抑制性抗体阴性13例,其LVEF为81.24%±2.33%,而抗体阳性23例(63.9%),其LVEF为62.04%±2.98%。结论扩张型心肌病心力衰竭患者中可能存在心肌抑制性抗体。
Objective To evaluate the presence of cardiac autoantibodies in patients with heart failure due to dilated cardiomyopathy using cardiac sonography to measure left ventricular ejection fraction (LVEF) in chick embryo heart. Methods Thirty-six patients with heart failure due to dilated cardiomyopathy and 23 patients with heart failure due to coronary heart disease were enrolled in this study. The serum levels of IgG were determined by random number table. The serum levels of IgG were determined by echocardiography . Results The LVEF was 81.03% ± 2.67% in patients with CHD, and 13 cases were negative in patients with dilated cardiomyopathy. The LVEF was 81.24% ± 2.33%, while the antibody was positive in 23 cases (63.9%). The LVEF was 62.04% ± 2.98%. Conclusions Myocardial inhibitory antibodies may exist in patients with dilated cardiomyopathy and heart failure.