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目的研究儿童发生重症感染时静脉注射丙种球蛋白的临床治疗效果。方法选择2010年4月—2012年9月三门峡市中医院诊治的240例重症感染的患儿,随机分为对照组和观察组,每组均为120例。对照组患者运用常规剂量丙种球蛋白(IVIG)治疗,观察组在对照组治疗的基础上加用200～300mg/(kg.d)的IVIG,每天注射一次,连续应用2d。比较两组患者的临床疗效。结果观察组患者总有效率为93.33%,对照组为81.66%,两组比较差异显著(P<0.05)。结论发生重症感染的患儿静脉注射丙种球蛋白后临床疗效较为显著,可以在临床上大力推广使用。
Objective To study the clinical effect of intravenous gamma globulin in children with severe infection. Methods From April 2010 to September 2012, 240 cases of severe infections diagnosed and treated in Sanmen Hospital of Traditional Chinese Medicine were randomly divided into control group and observation group, with 120 cases in each group. The patients in control group were treated with normal dose of IVIG. The observation group was given IVIG (200-300 mg / (kg.d)) once a day for 2 days continuously on the basis of the control group. The clinical efficacy of the two groups was compared. Results The total effective rate was 93.33% in the observation group and 81.66% in the control group, with significant difference between the two groups (P <0.05). Conclusion The clinical effect of intravenous injection of gamma globulin in children with severe infection is significant, which can be widely used clinically.