给乌拉坦麻醉大鼠侧脑室注射P物质(SP)10μg 引起的升压效应,可被脑室注射纳洺酮15μg 部分阻断。将抗β-内啡肽抗血清、抗甲啡肽抗血清及抗亮啡肽抗血清各10μl 分别注入侧脑室预处理60min 后,再注入 SP,其升压效应明显减弱;而抗强啡肽抗血清则对其无影响。上述结果提示:大鼠脑室注射 SP 引起的升压效应,可能是通过释放β-内啡肽和脑啡肽实现的。 Intravenous injection of substance P (SP) 10 ug in urethane anesthetized rats induced a vasopressor effect, which could be partly blocked by intracerebroventricular injection of 15 μg of naltrexone. Anti-β-endorphin antiserum, antithrombin antiserum and anti-leu-enkephalin antiserum each 10μl were injected into the lateral ventricular preconditioning 60min, then injected SP, the vasopressor effect was significantly reduced; and anti-dynorphin Antisera have no effect on it. The above results suggest that the vasopressor effect induced by intracerebroventricular injection of SP may be achieved through the release of β-endorphin and enkephalin.