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目的检测胃癌组织中尿激酶型纤溶酶原激活物(UPA)、血管标志物CD34的表达,并探讨其与胃癌侵袭和转移的关系及其相关性。方法采用免疫组化染色(SP法),按各自显色情况,对UPA进行半定量测定,对CD34进行定量测定。结果UPA及CD34在胃癌组织中高表达,并随病理分级的降低、淋巴转移的产生、远隔转移的发生、临床分期的提高而明显增高。胃癌中UPA与CD34的表达呈正相关。结论UPA、CD34对胃癌的发生、发展、侵袭和转移起重要的促进作用。UPA与CD34在胃癌的发生、发展、侵袭和转移相互促进,相互协调,关系密切。
Objective To detect the expression of urokinase-type plasminogen activator (UPA) and vascular marker CD34 in gastric cancer and to explore its relationship with the invasion and metastasis of gastric cancer. Methods Immunohistochemical staining (SP method), according to their color development, UPA semi-quantitative determination of CD34 quantitative determination. Results The expression of UPA and CD34 in gastric cancer tissues was high, and with the decrease of pathological grades, the occurrence of lymphatic metastasis, the distant metastasis and the clinical staging. There was a positive correlation between UPA and CD34 expression in gastric cancer. Conclusion UPA and CD34 play an important role in the carcinogenesis, development, invasion and metastasis of gastric cancer. UPA and CD34 in gastric cancer occurrence, development, invasion and metastasis mutual promotion, coordination, closely related.