论文部分内容阅读
目的:观察咳可合剂对热性哮喘发作期儿童肺通气功能、诱导痰中EOS及血清ECP水平变化的影响。方法:将62例热性哮喘发作期患儿随机分为两组,治疗组32例采用咳可合剂治疗,对照组30例采用咳喘宁口服液治疗,疗程均为7d。比较两组治疗前后肺功能、诱导痰中EOs及血清ECP的变化。结果:两组均能提高肺功能指标PEF和PEF%,降低EOS及ECP水平,治疗前后组内比较,差异有统计学意义(P<0.05),治疗组变化优于对照组(P<0.05)。结论:咳可合剂可通过调节患儿诱导痰中EOS及血清中ECP水平,减轻哮喘患儿的病理变化,从而控制哮喘的发作,咳可合剂是治疗小儿热性哮喘急性发作的有效中药。
Objective: To observe the effect of Ke Ke He Mixture on the pulmonary ventilation function in induced asthmatic children and the changes of EOS and serum ECP in induced sputum. Methods: Sixty-two children with fever asthma attack were randomly divided into two groups. 32 cases in the treatment group were treated with Keke Mixture, and 30 cases in the control group were treated with Kechuanning Oral Liquid. The treatment course was 7 days. The changes of lung function, induced sputum EOS and serum ECP in both groups before and after treatment were compared. Results: The PEF and PEF% of pulmonary function indexes and the EOS and ECP levels of both groups were significantly increased after treatment (P <0.05). The changes in the treatment group were better than those in the control group (P <0.05) . Conclusion: Keke Mixture can control the etiology of asthma by regulating EOS in sputum and ECP level in serum and reducing the pathological changes in children with asthma. Keke Mixture is an effective traditional Chinese medicine for the treatment of children with acute asthma attack.