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目的研究吡格列酮联合醋酸环丙孕酮对多囊卵巢综合症患者胰岛素抵抗及生殖激素水平的影响。方法选择2013年10月—2014年12月来我院治疗多囊卵巢综合症的患者108例,随机将其分成对照组和治疗组,每组各54例。对照组单独采用醋酸环丙孕酮治疗,治疗组同时加用吡格列酮治疗,观察两组患者治疗前后胰岛素抵抗指数(IR)及生殖激素水平。结果两组患者在生殖激素水平、胰岛素抵抗方面相比,差异有统计学意义(P<0.05)。结论对多囊卵巢综合症患者采用吡格列酮联合醋酸环丙孕酮共同治疗效果明显,能有效的改善胰岛素抵抗和生殖激素水平,可推广应用。
Objective To study the effects of pioglitazone combined with cyproterone acetate on insulin resistance and reproductive hormone levels in patients with polycystic ovary syndrome. Methods A total of 108 patients with polycystic ovary syndrome who were treated in our hospital from October 2013 to December 2014 were randomly divided into control group and treatment group, 54 cases in each group. The control group was treated with cyproterone acetate alone. The treatment group was treated with pioglitazone. The insulin resistance index (IR) and the level of reproductive hormone before and after treatment were observed. Results The two groups of patients in reproductive hormone levels, insulin resistance compared to the difference was statistically significant (P <0.05). Conclusions The combination of pioglitazone and cyproterone acetate is effective in patients with PCOS, which can effectively improve the level of insulin resistance and reproductive hormones and can be used widely.