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化疗药物对女性患者的卵巢具有细胞毒性作用,可引起不孕和早绝经等症状,这会严重影响其日后的生活质量和自信。促性腺激素释放激素类似物(GnRHa)对女性性腺轴有抑制作用。近年有研究表明GnRHa对化疗中的卵巢具有保护作用,可减少化疗对原始卵泡的损害,但其作用机制还不明确。就化疗对卵巢的损害和GnRHa对化疗中卵巢的保护作用及机制的研究进展进行综述
Chemotherapy drugs on female patients ovarian cytotoxicity can cause infertility and early menopause and other symptoms, which will seriously affect their quality of life and confidence in the future. Gonadotropin-releasing hormone analogues (GnRHa) inhibit the female gonadal axis. In recent years, studies have shown that GnRHa on ovarian chemotherapy has a protective effect, can reduce chemotherapy damage to the primordial follicles, but its mechanism of action is not yet clear. A review on the damage of ovary induced by chemotherapy and the protective effect and mechanism of GnRHa on ovary in chemotherapy