给Dutch-belted兔饲喂2％的胆固醇食物8周,所产生的动脉粥样硬化斑块覆盖了主动脉管腔表面的37.2％ 3.5％。并观察到主动脉弓也有胆固醇和甘油三酯堆积。以每天两次每公斤体重各40毫克的尼卡地平(Nicardipihe)和硝苯啶(Nifedipine)口服8周,分别减少斑块面积49.2％和58.7％。同时主动脉弓的胆固醇堆积也分别减少74.5％和69％。堆积的甘油三酯全部消除。虽然尼卡地平可使每毫升d<1.006克 Dutch-belted rabbits were fed a 2% cholesterol diet for 8 weeks, producing atherosclerotic plaques covering 37.2% of the aortic luminal surface 3.5%. Aortic arch also observed accumulation of cholesterol and triglycerides. Nicardipihe and Nifedipine, 40 mg twice daily, for 8 weeks, reduced plaque area by 49.2% and 58.7%, respectively. At the same time, cholesterol accumulation in the aortic arch decreased by 74.5% and 69%, respectively. Accumulation of triglycerides all eliminated. Although nicardipine can make d <1.006 grams per milliliter