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目的:合成白藜芦醇类似物,以期获得抗氧化活性更好的活性分子。方法:将白藜芦醇的A环分别用活性杂环川芎嗪和4-氨基喹啉替换。考察目标合物9,12及中间体8,11对DPPH自由基的清除作用。结果与结论:设计合成了2个未见文献报道的白藜芦醇类似物,其结构经MS和1H-NMR图谱确证。化合物9,11和12对DPPH自由基的清除作用较白藜芦醇减弱,化合物8在低浓度时具有比白藜芦醇更强的DPPH自由基清除能力,具有潜在的抗氧化作用。
OBJECTIVE: To synthesize resveratrol analogues in order to obtain active molecules with better antioxidant activity. Methods: The A ring of resveratrol were replaced by the active heterocyclic tetramethylpyrazine and 4-aminoquinoline respectively. The scavenging effects of target compounds 9,12 and intermediates 8,11 on DPPH free radical were investigated. RESULTS AND CONCLUSION: Two resveratrol analogues were reported. Their structures were confirmed by MS and 1H-NMR. Compounds 9, 11 and 12 scavenging DPPH free radicals more effectively than resveratrol. Compound 8 has a stronger DPPH radical scavenging ability than resveratrol at low concentrations, and has potential antioxidant activity.