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你刊1982年第6期第53页“齐墩果酸”一文把齐墩果酸与庆四素列为同一药物。这是不对的。查齐墩果酸为五环三萜类化合物,而庆四素(雪胆素)为四环三萜类苦味素“。熔点:前者为302～307℃:后者为222～227℃。性状:齐墩果酸为白色针状结晶性粉末,质轻,无臭,无味。不溶于水,微溶于乙醇、氯仿、丙酮中,可溶于热乙醇、乙醚及苯中。雪胆素为白色的结晶性粉末,无臭,味苦,遇碱不稳定。在乙醇、甲醇或氯仿中易溶,在丙酮或醋酸乙酯中溶解,在乙醚中微溶,在水、石油醚或环己烷中不溶。药理作用与临床用途不同:齐墩果酸对四氯化碳引起的大鼠急慢性肝损伤有明显的保护作用……。实验证明还具有促进肝细胞再生的作用。用于治疗急性、迁慢性肝炎均有效,临床证明有降酶、降浊和改
In your article, 1982, No. 6, page 53, ”Oleanolic Acid," the article lists oleanolic acid and qingsisu as the same drugs. this is not right. Chaqiedao acid is a pentacyclic triterpene compound, while Qingqingsu (snow choline) is a tetracyclic triterpene bitterin.” Melting point: The former is 302 to 307°C: the latter is 222 to 227°C. Properties: Oleanolic acid is a white needle crystal powder, light weight, odorless, tasteless, insoluble in water, slightly soluble in ethanol, chloroform, acetone, soluble in hot ethanol, ethyl ether and benzene. White crystalline powder, odorless, bitter, unstable to alkali, easily soluble in ethanol, methanol or chloroform, soluble in acetone or ethyl acetate, slightly soluble in ether, in water, petroleum ether or ring It is insoluble in hexane.The pharmacological effect is different from clinical use: Oleanolic acid has obvious protective effect on carbon tetrachloride-induced acute and chronic hepatic injury in rats.... Experiments have also proved to have the effect of promoting hepatocyte regeneration. Treatment of acute, chronic hepatitis is effective, clinically proven to reduce the enzyme, reduce turbidity and change