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目的探讨云南哈尼族人群与人类免疫缺陷病毒(HIV)感染相关的SDF1-3’A、CCR2-64I、CX3CR1基因多态性分布。方法通过MassARRAY检测技术分析了78例云南哈尼族人群SDF1-3’A、CCR2-64I、CX3CR1单核苷酸多态性,通过与国内外研究结果比较,探讨其特点。结果在SDF1-3’A位点上明显高于美国黑人;在CCR2-64I位点上明显高于汉族、黎族、仫佬族、美国黑人和高加索人;在CX3CR1-V249I和CX3CR1-T280M位点,均明显低于高加索人。结论云南哈尼族人群可能对HIV感染具有较强的抵抗力,能延缓艾滋病的发病进程。
Objective To investigate the distribution of SDF1-3’A, CCR2-64I and CX3CR1 gene polymorphisms associated with human immunodeficiency virus (HIV) infection in Yunnan Hani population. Methods The genetic polymorphisms of SDF1-3’A, CCR2-64I and CX3CR1 in 78 Hani ethnic population of Yunnan were analyzed by MassARRAY technique. The characteristics of SDF1-3’A, CCR2-64I and CX3CR1 were compared with those of other countries. The results were significantly higher in SDF1-3’A locus than in American blacks; in CCR2-64I locus, they were significantly higher than those in Han, Li, Mulao, Afro-Americans and Caucasians; at CX3CR1-V249I and CX3CR1-T280M loci , Were significantly lower than Caucasians. Conclusions The Hani population in Yunnan may have strong resistance to HIV infection and delay the onset of AIDS.