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目的探讨脑膜血管瘤病的临床病理学特征。方法复习2例脑膜血管瘤病的临床资料,对影像学和病理学形态进行观察,并结合相关文献加以分析。结果 2例均以癫为主要症状;病变位于增生的软脑膜下并侵入大脑皮质,小血管及周围梭形细胞增生明显,伴有大量砂砾体形成。免疫组化标记无特异性,vimentin通常(+)。影像学检查示有不同程度钙化,无其他特殊表现。病灶切除后癫控制良好。结论脑膜血管瘤病是一种罕见的颅内良性病变,临床病理表现多样,造成诊断困难。正确的诊断需结合影像学资料及详细的组织学检查,方可避免过度治疗。
Objective To investigate the clinicopathological features of meningeal angiomatosis. Methods The clinical data of 2 cases of meningeal hemangiomatosis were reviewed. The imaging and pathological morphology were observed and analyzed with relevant literature. Results The epilepsy was the main symptom in both cases. The lesion was located in the hyperplastic leptomeningeal and invaded the cerebral cortex. Small blood vessels and the surrounding spindle cells proliferated obviously with a large amount of grit. Immunohistochemical nonspecific labeling, vimentin usually (+). Radiographic examination showed varying degrees of calcification, no other special performance. Epilepsy control after focal resection. Conclusion Meningeal angiomatosis is a rare intracranial benign disease, with various clinical and pathological manifestations, which makes the diagnosis difficult. Correct diagnosis should be combined with imaging data and detailed histological examination before over-treatment can be avoided.