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近年来随着对子宫内膜癌发病机制及分子遗传学改变的认识,子宫内膜癌的前期病变也引起研究者的关注。WHO(2014)女性生殖细胞肿瘤分类中,引入了子宫内膜样上皮内瘤变(EIN)的概念,将子宫内膜增生分为良性增生和EIN,认为只有EIN是子宫内膜癌的前期病变,具有肿瘤的性质,因此鉴别良性子宫内膜增生和EIN具有重要的临床意义。本文将对子宫内膜样上皮内肿瘤概念的提出、病理形态学特征以及目前有关EIN诊断的分子标记物进行综述。
In recent years, with the understanding of the pathogenesis of endometrial cancer and molecular genetic changes, early lesions of endometrial cancer also caused the researchers’ attention. The concept of endometrial-like intraepithelial neoplasia (EIN) was introduced in the WHO (2014) classification of female germ cell tumors to classify the endometrial hyperplasia as benign hyperplasia and EIN, and to conclude that only EIN is an early stage of endometrial cancer , With the nature of the tumor, so the identification of benign endometrial hyperplasia and EIN has important clinical significance. This article will review the concept of endometrial-like intraepithelial neoplasia, pathomorphological features, and current molecular markers for the diagnosis of EIN.