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目的:探讨脂蛋白(a)、C反应蛋白、血尿酸和血清胆红素在心脑血管疾病诊断中的临床应用价值。方法:用全自动贝克曼生化仪AU-680型检测50例正常人(健康对照组)、150例冠心病组、100例脑梗死组、180例高血压组的脂蛋白(a)、C反应蛋白、血尿酸和血清胆红素水平。结果:冠心病组、脑梗死组、高血压组与正常对照组比较:LP(a)、CRP、SUA、TBIL和DBIL均差异显著,具有统计学意义(P<0.05);冠心病组、脑梗死组和高血压组三组之间分别比较:LP(a)、CRP、SUA、TBIL和DBIL均有差异显著,具有统计学意义(P<0.05)。结论:联合检测LP(a)、CRP、SUA、TBIL和DBIL指标是心脑血管疾病灵敏指标,其浓度变化对于心脑血管疾病的发生和进展情况具有重要参考意义,可为心脑血管疾病提供早期的诊断预防和治疗参考依据。高LP(a)、高CRP和高SUA分别是动脉粥样硬化的独立危险因子,也是动脉粥样斑块不稳定的重要因素。因此,以上参数指标都明显异常时需引起临床医师的高度重视,应积极对患者进行干预治疗,以免引起疾病进一步发展或加重趋势,从而提高生存患者的生活质量。
Objective: To investigate the clinical value of lipoprotein (a), C-reactive protein, serum uric acid and serum bilirubin in the diagnosis of cardiovascular and cerebrovascular diseases. Methods: The serum levels of lipoprotein (a) and C (superscript +) in 50 normal subjects (healthy control group), 150 coronary heart disease group, 100 cerebral infarction group and 180 hypertensive patients were detected by automatic Beckman biochemical analyzer AU- Protein, serum uric acid and serum bilirubin levels. Results: The levels of LP (a), CRP, SUA, TBIL and DBIL in coronary heart disease group, cerebral infarction group and hypertension group were significantly different from those in normal control group (P <0.05) There was significant difference between the three groups of infarction group and hypertension group (P <0.05). There was significant difference between LP (a), CRP, SUA, TBIL and DBIL. Conclusion: The combined detection of LP (a), CRP, SUA, TBIL and DBIL indicators is a sensitive indicator of cardiovascular and cerebrovascular diseases. The change of concentration has important reference value for the occurrence and progression of cardiovascular and cerebrovascular diseases and may provide cardiovascular and cerebrovascular diseases Early diagnosis and treatment of prevention and treatment reference. High LP (a), high CRP, and high SUA were independent risk factors for atherosclerosis, respectively, and were also an important factor for atherosclerotic plaque instability. Therefore, when the above parameters are obviously abnormal, clinicians should pay close attention to it. Patients should be actively treated to avoid further development or aggravation of the disease so as to improve the quality of life of the surviving patients.