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目的:评估瓦茸多糖体对于照射过γ-射线小白鼠脾脏损伤之修复作用。方法:本研究所使用之药品为瓦茸多糖体(Coriolus versicolor polysaccharides,CVP,PSK)。瓦茸(又名黑云茸)多糖体是一种与蛋白质结合的多糖体,CVP是从培养的担子菌类胡孙眼科瓦茸之菌丝体精制而成。本研究选取6—8周大之ICR种系小白鼠180只,分为3组:A组为正常对照组;B组为辐射对照组,仅接受1Gyγ射线的全身辐射;C组为实验组,于接受1Gyγ-射线之次日起10d,每日用胃管喂以CVP60mg·kg~(-1)。于辐射后的第5,12,19,26及33日,分5批处理,每批每组各取小鼠8只测量体重后,取出脾脏称重,制成脾脏细胞的悬浮液。用[~3H]TdR追踪法测定脾脏细胞之DNA合成速率。结果:小鼠在接受γ-射线后,其脾脏重量及脾脏细胞之DNA合成速率皆有下降。在照射后接受CVP处理之C组,CVP能促进提早恢复因γ-射线所导致的抑制效果。结论:CVP对于照过γ-射线小白鼠之脾损伤具有显著修复作用。
PURPOSE: To evaluate the repair effect of polysaccharides of Vallor Velvet on spleen injury in irradiated γ-ray mice. Methods: The drugs used in this study were Coriolus versicolor polysaccharides (CVP, PSK). Vase (also known as black velvet) polysaccharide is a protein-bound polysaccharide, CVP is from the culture of the basidiomycetes Hu son Ophiopogon mycelia refined. In this study, 180 ICR germ-line mice, 6-8 weeks old, were randomly divided into 3 groups: group A was normal control group, group B was radiation control group, which received only 1Gyγ-ray whole body radiation; group C was experimental group, 1Gyγ-ray the next day 10d, fed with stomach daily CVP60mg · kg ~ (-1). On the 5th, 12th, 19th, 26th and 33rd days after irradiation, the cells were divided into 5 batches. Eight batches of mice in each group were weighed and the spleen was taken out and weighed to prepare a suspension of spleen cells. The DNA synthesis rate of spleen cells was measured by [~ 3H] TdR tracing method. RESULTS: After receiving γ-rays, the mouse’s spleen weight and DNA synthesis rate of spleen cells both decreased. In Group C, which received CVP after irradiation, CVP could promote early recovery of the suppressive effect due to γ-rays. CONCLUSIONS: CVP has a significant repair effect on splenic injury in irradiated γ-ray mice.