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肿瘤血管发生是肿瘤迅速增殖和转移的重要条件,但各种特殊的因子在瘤性增殖中的作用很难确定。本研究采用mRNA原位杂交法检测血管内皮生长因子(vascular endothelial growth factor,VEGF)在3份正常卵巢、68份早期卵巢癌石蜡包埋组织中的表达,并分析VEGF过度表达对早期卵巢癌患者预后判断的临床价值。 研究对象为1976～1994年68例Ⅰ、Ⅱ期交界性和浸润性卵巢癌。交界性13例,浸润性55例。Ⅰa期14例,Ⅰb期5例,Ⅰc期21例,Ⅱa期2例,Ⅱb期14
Tumor angiogenesis is an important condition for rapid tumor proliferation and metastasis, but the role of various special factors in tumorigenesis is difficult to determine. In this study, the mRNA in situ hybridization was used to detect the expression of vascular endothelial growth factor (VEGF) in 3 normal ovarian tissues and 68 early stage ovarian cancer paraffin-embedded tissues. VEGF overexpression was analyzed in patients with early stage ovarian cancer Prognosis of the clinical value. The object of study was 68 cases Ⅰ and Ⅱ borderline and invasive ovarian cancer from 1976 to 1994. 13 cases of borderline, invasive 55 cases. 14 cases of stage Ia, 5 cases of stage Ib, 21 cases of stage Ic, 2 cases of stage IIa and 14 cases of stage IIb