【摘 要】
：
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC).CIP2A plays an\'oncogenic nexus\' to participate in the tumorigenesis and chem
【机 构】
：
Department of Respiratory Medicine, The Second Hospital of Shandong University, Jinan 250033, China;
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Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC).CIP2A plays an\'oncogenic nexus\' to participate in the tumorigenesis and chemoresistance in several cancer types.AKT and mTORC1 overactivation are detected in NSCLC and many other cancers.Previous studies found that the CIP2A/AKT/mTOR pathway controls cell growth,apoptosis,autophagy process.Polyphyllin Ⅰ (PPⅠ) and polyphyllin Ⅶ (PPⅦ) are natural components extracted from Paris polyphylla that display anti-cancer properties.In the present study,we investigated whether PPⅠ and PPⅦ can be used in the cisplatin (DDP)-resistant human NSCLC cell line A549/DDP.Results demonstrated that PPⅠ and PPⅦ treatment significantly suppressed A549/DDP cell proliferation,migration,invasion and EMT,induced apoptosis and autophagy.Further examination of the mechanism revealed that the PPⅠ and PPⅦ significantly upregulated the p53,induced caspase-dependent apoptosis and suppressed the CIP2A/AKT/mTOR pathway.The activation of autophagy was mediated through PPⅠ and PPⅦ induced inhibition of mTOR.We propose that PPⅠ and PPⅦ might be developed as candidate drugs for DDP-resistant NSCLC.
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