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目的进一步探讨多巴胺D4受体(DRD4)基因第三外显子48bp可变重复序列(VNTR)多态性与注意缺陷多动障碍(ADHD)儿童青少年的相关情况。方法通过中国知网(CNKI)、万方、维普、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、EBSCO、Ovid、Springer数据库,检索国内外关于DRD4基因第3外显子48bp VNTR多态性与儿童ADHD关联性的病例对照研究,采用Meta分析综合定量分析纳入文献。结果 20篇文献共纳入3 658例ADHD患者和6 272例对照,Meta分析结果提示在总人群中4R、7R和长片段ADHD组与对照组相比差异均有统计学意义,其他片断ADHD组与对照组相比差异均无统计学意义。亚洲人群中各种重复片段的ADHD组与对照组相比差异均无统计学意义。非亚洲人群中4R、7R、短片断和长片段(>4R)ADHD组与对照组相比差异均有统计学意义,其余重复片段差异均无统计学意义。结论 Meta分析显示总人群DRD4 48bp 4R、7R、长片段(>4R)与ADHD间有相关性;非亚洲人群DRD4 48bp4R、7R、短片段、长片段(>4R)与ADHD间有相关性;亚洲人群48bp VNTR多态性与ADHD间均未显示有相关性。
Objective To investigate the relationship between the 48 bp variable repeat (VNTR) polymorphism of exon 3 of dopamine D4 receptor (DRD4) gene and children and adolescents with attention deficit hyperactivity disorder (ADHD). Methods The 48 bp VNTR polymorphism of exon 3 of DRD4 gene was searched by CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, EBSCO, Ovid and Springer databases. A case-control study of the association of sexual and childhood ADHD was included in the literature using meta-analysis of comprehensive quantitative analysis. Results A total of 3 658 ADHD patients and 6 272 controls were included in the 20 articles. The results of Meta-analysis indicated that there was significant difference between the 4R, 7R and long ADHD groups and the control group in the general population. Other ADHD groups There was no significant difference between the control group and the control group. There was no significant difference between ADHD group and control group in the Asian population. The non-Asian population 4R, 7R, short fragment and long fragment (> 4R) ADHD group compared with the control group differences were statistically significant, the rest of the repeat fragments showed no significant difference. Conclusions Meta-analysis showed that DRD4 48bp 4R, 7R and long fragments (> 4R) were associated with ADHD in the general population. There was a correlation between DRD4 48bp4R, 7R, short fragment and long fragment (> 4R) No association was found between the 48 bp VNTR polymorphism in the population and ADHD.