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不明原因复发性流产(URSA)是多基因控制的复杂疾病,发生率约占复发性流产的50%。近年大量研究表明,URSA与基因多态性有密切的关系,免疫系统中人类白细胞抗原(HLA)、细胞因子基因多态性;遗传性易栓症相关基因纤溶酶原激活抑制物(PAI-1)、V因子、人类亚甲基四氢叶酸还原酶(MTHFR)及载脂蛋白等基因多态性均与URSA有关;另外,孕激素受体(PR)、胰岛素生长因子等基因多态性也与URSA有关。因此,从基因水平上阐明URSA的发病机制,给临床预防、治疗和预后提供指导,是目前URSA病因学研究的热点。
Unexplained recurrent spontaneous abortion (URSA) is a multi-gene control of complex diseases, the incidence of recurrent abortion about 50%. In recent years, a large number of studies have shown that, URSA and genetic polymorphisms are closely related to the immune system, human leukocyte antigen (HLA), cytokine gene polymorphisms; genetic thrombolytic disease-related gene plasminogen activator inhibitor (PAI- 1, V factor, human MTHFR and apolipoprotein were all related to URSA. In addition, polymorphisms of progesterone receptor (PR) and insulin growth factor Also related to URSA. Therefore, elucidating the pathogenesis of URSA at the gene level and providing guidance for clinical prevention, treatment and prognosis are the hot spots in the research of etiology of URSA at present.