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目的 :研究乙型肝炎病毒 1896A变异对HBV复制的影响。方法 :采用错配引物聚合酶链反应 (PCR)—限制性片段长度多态性 (RFLP)分析 ,对 10 5例HBVDNA阳性的HBV感染者进行HBV 1896A变异及HBVDNA定量检测。结果 :1896A变异组HBeAg阴性率较非 1896A变异组高 (P <0 .0 0 5 )。HBV 1896A变异组HBVDNA含量在HBeAg+ 病例 (10 8.2 3± 0 .96 copy/ml,vs 10 7.6 7± 0 .6 7copy/ml,P <0 .0 1)及HBeAg- 病例 (10 7.99± 1 .33copy /mlvs 10 7.0 8± 1 .4 9coyp/ml,P <0 .0 1)中均较非HBV 1896A变异组高。 结论 :1896A变异在阻断HBeAg表达的同时促进HBV的复制。
Objective: To study the effect of hepatitis B virus 1896A mutation on HBV replication. Methods: HBV 1896A mutation and HBVDNA were quantitatively detected in 10 5 HBVDNA positive HBV infected patients by polymerase chain reaction-restriction fragment length polymorphism (RFLP). Results: The negative rate of HBeAg in 1896A mutation group was higher than that in non-1896A mutation group (P <0.05). The HBVDNA content in HBV 1896A mutation group was significantly higher in HBeAg + cases (10 8.23 ± 0.96 copy / ml, vs 10 7.67 ± 0.67 pg / ml, P <0.01) and HBeAg- cases (10 7.99 ± 1. 33copy / ml vs 10 7.0 8 ± 1.49coyp / ml, P <0.01) than in non-HBV 1896A mutation group. Conclusion: The 1896A mutation promotes the replication of HBV while blocking the expression of HBeAg.