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宫颈小细胞神经内分泌癌是一种罕见的妇科肿瘤,因其恶性度高、进展快、复发率高,易早期发生淋巴结转移及血行播散,故预后极差。高危型人乳头状瘤病毒(HPV)感染是其主要病因。神经内分泌标志物有助于其诊断。手术、放疗和化疗相结合的综合治疗能明显改善早期肿瘤患者的预后。本文就其病理学、分子生物学及诊断、治疗上的研究进展等进行综述。
Cervical small cell neuroendocrine cancer is a rare gynecological cancer, because of its high degree of malignancy, rapid progress, high recurrence rate, early occurrence of lymph node metastasis and hematogenous spread, so poor prognosis. High-risk human papilloma virus (HPV) infection is the main cause. Neuroendocrine markers contribute to their diagnosis. The combined treatment of surgery, radiotherapy and chemotherapy can significantly improve the prognosis of patients with early cancer. This article reviews the pathology, molecular biology, diagnosis and treatment progress.