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采用双盲双模拟对照多中心实验，临床评价了丁丙诺啡（Ｂｕｐ）舌下含片（每片０．２ｍｇ）的镇痛效果，对照药为硫酸吗啡普通片。结果表明：（１）Ｂｕｐ用于缓解手术后急性中度疼痛０．２ｍｇ－０．４ｍｇ丁丙诺啡的临床镇痛效果与１０ｍｇ吗啡相当；（２）丁丙诺啡片用于缓解中度疼痛，其一次剂量０．２ｍｇ与０．４ｍｇ的临床镇痛效果几乎无差别，提示每次应用１片即可；（３）Ｂｕｐ片用于缓解晚期癌症慢性中度疼痛，每次剂量０．２－０．８ｍｇ，一日三次，可使８０％的疼痛患者得到中度以上缓解，临床镇痛总有效率９１．６７％，显效率８６．１１％。本试验，日剂量加大到１．２－２．４ｍｇ时，完全缓解率达到６０％，中度以上缓解率达到９５％，给药间隔时间可延长到６－８ｈ，显示本药具有中长镇痛时效。可以认为，通过剂量调整能使中度癌痛患者达到无疼痛；（４）Ｂｕｐ的不良反应主要为头晕、恶心、呕吐，服药当天较重，分别可达３０％、３０％和２０％左右。１ｗｋ内明显下降。少数人可有头痛、皮肤瘙痒、皮疹、排尿困难等。开放试验思睡发生率２ｗｋ内一直在２０％－３０％左右，明显高于对照试验丁丙诺啡组；（５）未发现丁丙诺啡对呼吸、血压、心率造成明显影响。经２ｗｋ用药观察，血?
A double-blind, double-dummy, multicenter trial was used to evaluate the analgesic effect of sublingual buprenorphine (0.2 mg per tablet) in buprenorphine (Bup). The reference drug was morphine sulfate. The results showed that: (1) Bup was used to relieve the acute analgesic effect of 0.2mg-0.4mg buprenorphine after surgery, which was equivalent to 10mg morphine; (2) Buprenorphine tablets were used to relieve moderate Pain, a dose of 0.2mg and 0.4mg clinical analgesic effect almost no difference, suggesting that each application can be; (3) Bup tablets for the treatment of chronic cancer of chronic moderate pain, each dose 0. 2-0.8mg, three times a day, can make 80% of patients with moderate to moderate pain relief, the total effective rate of clinical analgesia was 91.67%, markedly effective rate of 86.11%. The test, the daily dose increased to 1.2-2.4mg, the complete remission rate reached 60%, moderate remission rate of 95%, dosing interval can be extended to 6-8h, indicating that the drug has a long Pain and aging. It can be considered that the dose adjustment can make patients with moderate cancer pain achieve no pain; (4) The adverse reactions of Bup are mainly dizziness, nausea and vomiting, and they are heavier on the day of taking medicine, reaching up to 30%, 30% and 20% respectively. 1wk significantly decreased. A few people may have headache, itchy skin, rashes, dysuria and so on. The prevalence of open sleep test was 20% -30% within 2 weeks, which was significantly higher than that of the control group. (5) No significant effect of buprenorphine on respiration, blood pressure and heart rate was found. After 2wk medication observation, blood?