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目的:研究频谱房(骏丰牌)联合来氟米特、柳氮磺吡啶治疗强直性脊柱炎患者的疗效观察。方法:选取我院强直性脊柱炎患者120例,随机分成治疗组与对照组。其中,治疗组60例,对照组60例。治疗组给予骏丰频谱房联合来氟米特、柳氮磺吡啶进行治疗。对照组采用来氟米特、柳氮磺吡啶进行治疗。观察治疗前及治疗后4周、8周两组患者的临床症状和体征(腰骶部疼痛、睡眠障碍、疲劳等症状)改善情况,对血沉、C-反应蛋白等检查项目,分别于治疗前、治疗后4周及8周进行复查并做详细记录。同时观察不良反应,发生情况并详细记录。结果:治疗4周后,治疗组在腰骶部疼痛、睡眠障碍、疲劳等症状改善、血沉、C-反应蛋白等指标上较对照组有显著改善。治疗8周后,治疗组有效率已达95.00%,高于对照组的81.60%。多项观察指标差异有统计学意义(P<0.05)。结论:骏丰频谱房联合来氟米特、柳氮磺吡啶治疗强直性脊柱炎,疗效明显,值得进一步推广。
Objective: To study the efficacy of spectrum room (Junfeng brand) combined with leflunomide and sulfasalazine in treatment of patients with ankylosing spondylitis. Methods: 120 cases of ankylosing spondylitis in our hospital were randomly divided into treatment group and control group. Among them, 60 cases in the treatment group and 60 cases in the control group. The treatment group was given Junfeng spectrum room combined with leflunomide, sulfasalazine for treatment. The control group was treated with leflunomide and sulfasalazine. The clinical symptoms and signs (lumbosacral pain, sleep disturbance, fatigue and other symptoms) of the two groups before and after treatment for 4 weeks and 8 weeks were observed. The echocardiographic, C-reactive protein and other test items were observed before treatment , 4 weeks and 8 weeks after treatment for review and make a detailed record. At the same time observe the adverse reactions, the occurrence and detailed records. Results: After 4 weeks of treatment, the treatment group showed significant improvement in lumbosacral pain, sleep disorders, fatigue and other symptoms, as well as ESR and C-reactive protein compared with the control group. After 8 weeks of treatment, the effective rate of the treatment group reached 95.00%, which was 81.60% higher than that of the control group. A number of observation indicators were statistically significant (P <0.05). Conclusion: Junfeng spectrum room combined with leflunomide, sulfasalazine treatment of ankylosing spondylitis, significant effect, worthy of further promotion.