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偏头痛发病部位在脑膜血管上，5－HT系统参与首要作用，多巴胶（DA）系统居其次。急性发作前期释放大量S-HT，作用于脑膜血管，使血管收缩；急性发作时，血管过度舒张，浆液外渗，形成无菌性炎症，刺激冲动从三叉神经上传，出现恶心、呕吐、头痛、怕光等神经症状。偏头痛发作时，DA系统处于超海已发作期应用5-HT1D受体激动剂和D2受体拮抗剂治疗；长期性预防发作可用5－HT2受体桔抗剂和DA受体激动剂。舒马曲坦是当今最有选择性的5-HT1D受体激动剂，适用于急性治疗。
The migraine site was located on the meningeal blood vessels. The 5-HT system was involved in the primary effect, followed by the DA system. Acute exacerbation of the release of a large number of S-HT, the role in the meninges blood vessels, the vasoconstriction; acute attack, vascular over-relaxation, extravasation of serous to form aseptic inflammation, stimulate the impulse to upload from the trigeminal nerve, nausea, vomiting, Fear of light and other neurological symptoms. In migraine attacks, the DA system is in the ultra-sea phase with 5-HT1D receptor agonists and D2 receptor antagonists; 5-HT2 receptor antagonists and DA receptor agonists are available for long-term prevention. Sumatriptan is today the most selective 5-HT1D receptor agonist, suitable for acute treatment.