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目的 :研究洛美沙星对大鼠血胰屏障的通透性。方法 :经尾静脉推注洛美沙星 (20mg/kg) ,在规定的时间点取样 ,用高效液相色谱法 (HPLC)测定胰腺、肝脏组织和血清中药物的含量。结果 :洛美沙星在大鼠体内过程符合二室模型 ;血清、胰腺、肝脏组织药物浓度在5min时最高 ,分别为65 551μg/ml、48 801μg/g、84 121μg/g ,然后持续下降 ;10min时胰组织的药物浓度已高于血清 ,480min胰组织中仍维持较高浓度 ;药物对血胰屏障的通透率 (PR)在5min时最低 (0 744) ,然后上升 ,480min时达到3 817。结论 :静脉推注洛美沙星后 ,药物对血胰屏障具有良好的通透性 ,值得向临床推荐用于预防和治疗胰腺感染
Objective: To study the permeability of lomefloxacin to the blood-pancreas barrier in rats. Methods: Lomefloxacin (20 mg / kg) was injected through the tail vein and samples were taken at defined time points. The contents of the drugs in the pancreas, liver tissue and serum were determined by high performance liquid chromatography (HPLC). RESULTS: Lomefloxacin was in a two-compartment model in rats. The serum, pancreas and liver tissue concentrations were highest at 5 min after treatment with 65 551 μg / ml, 48 801 μg / g and 84 121 μg / g, respectively, The concentration of drug in pancreatic tissue was higher than that in serum at 480 min, and remained at a high level in 480 min pancreatic tissue. The permeability (PR) of drug to blood-pancreas barrier was the lowest (0 744) at 5 min and then increased to 3817 . Conclusion: After intravenous injection of lomefloxacin, the drug has a good permeability on the blood-pancreas barrier and is worthy of clinical recommendation for prevention and treatment of pancreatic infection