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目的探讨替硝唑局部用药治疗牙周炎的临床效果及安全性。方法选取2015年2月—2016年8月收治的106例牙周炎患者,随机分为对照组和观察组各53例,对照组予以替硝唑口服治疗,观察组予以替硝唑局部用药,比较两组治疗效果及不良反应,采用SPSS20.0软件对数据进行统计分析,P<0.05为差异有统计学意义。结果治疗后观察组牙周探诊深度、菌斑指数、牙龈出血指数、牙龈附着水平分别为(2.03±0.31)mm、(0.98±0.26)、(0.63±0.21)、(1.94±0.35)mm,对照组分别为(2.95±0.64)mm、(1.42±0.51)、(1.39±0.46)、(3.05±0.54)mm,两组比较差异均有统计学意义(t=9.41、5.596、10.942、12.558,均P<0.05);观察组不良反应率为7.55%,对照组为22.64%,两组比较差异有统计学意义(χ~2=4.711,P<0.05)。结论采用替硝唑局部治疗能够快速提高牙周炎治疗效果,可加快炎症消退时间,且不良反应少,安全性高。
Objective To investigate the clinical effect and safety of topical tinidazole in the treatment of periodontitis. Methods A total of 106 patients with periodontitis admitted from February 2015 to August 2016 were randomly divided into control group and observation group (n = 53). The control group was treated with tinidazole orally. The observation group was given topical tinidazole, The therapeutic effects and adverse reactions of the two groups were compared. The data were analyzed by SPSS20.0 software. P <0.05 was considered statistically significant. Results After treatment, the probing depth, plaque index, gingival bleeding index and gum attachment in observation group were (2.03 ± 0.31) mm, (0.98 ± 0.26), (0.63 ± 0.21) and (1.94 ± 0.35) mm respectively, (2.95 ± 0.64) mm, (1.42 ± 0.51), (1.39 ± 0.46) and (3.05 ± 0.54) mm respectively in the control group, with significant differences between the two groups (t = 9.41,5.596,10.942,12.558, (P <0.05). The rate of adverse reactions in the observation group was 7.55% and that in the control group was 22.64%. There was significant difference between the two groups (χ ~ 2 = 4.711, P <0.05). Conclusion The local treatment with tinidazole can rapidly improve the treatment effect of periodontitis, which can accelerate the time of inflammation subsidence with less adverse reactions and high safety.