论文部分内容阅读
目的探讨过氧化物还原酶4(Prx 4)在胃癌组织中的表达及其临床意义。方法免疫组织化学法检测52例胃癌(A组)、20例胃不典型增生(B组)和33例胃炎(C组)组织中Prx 4的表达水平,分析其与胃癌临床病理学参数之间的关系。结果 A组Prx 4表达阳性率为90.4%,明显高于B组和C组的5.0%和9.1%(P<0.05)。Prx 4在胃癌组织中的表达与各临床病理参数之间均没有明显的相关性(P>0.05)。结论 Prx 4在胃癌组织中高表达,可能在胃癌的发病过程中起一定作用。
Objective To investigate the expression of peroxiredoxin 4 (Prx 4) in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of Prx 4 in 52 cases of gastric cancer (group A), 20 cases of gastric atypical hyperplasia (group B) and 33 cases of gastritis (group C), and the correlation between the expression of Prx 4 and clinicopathological parameters of gastric cancer Relationship. Results The positive rate of Prx 4 in group A was 90.4%, which was significantly higher than 5.0% and 9.1% in group B and C (P <0.05). There was no significant correlation between the expression of Prx 4 and the clinicopathological parameters in gastric cancer (P> 0.05). Conclusion Prx 4 is highly expressed in gastric cancer and may play a role in the pathogenesis of gastric cancer.