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目的 确证二硫化碳（ＣＳ２ ）作业女工妊娠时间延长的现象，并探讨妊娠时间作为标志生殖损伤筛选指标的可行性。方法 在回顾性研究现场，追踪观察欲生育女工的妊娠时间。结果 ①２５７ 名接触组女工第 １ 个月经周期妊娠率为２７．２％ ，前 ３ 个月累积时间妊娠率为５８．７％ ，１ 年内累积时间妊娠率为 ９３．７％ ，均明显低于对照组（分别为３５．８％ ，６９．１％和 ９７．０％ ，Ｐ 值分别为 ０．０１８１，０．００４０ 和０．０１４５）；②单纯女工或夫妻双方接触ＣＳ２ 时其妊娠率均低于夫妻双方不接触ＣＳ２ 时的妊娠率；夫妻双方或单纯女工接触ＣＳ２，时间妊娠率无明显差异；③ＣＳ２ 作业女工妊娠所需时间与其接触ＣＳ２ 浓度（ｒ＝ ０．１１９８，Ｐ＝ ０．０２４）及接触时间（ｒ＝ ０．２７９９，Ｐ＝ ０．０００）呈正相关关系。结论 女工从事ＣＳ２ 作业可致妊娠所需时间延长，降低生育能力；妊娠时间可作为标志女性生殖损伤效应的初筛指标。
Objective To confirm the phenomenon of prolonged pregnancy time of women workers exposed to carbon disulfide (CS2) and explore the feasibility of using gestational time as a marker of reproductive injury screening. Methods At the retrospective study site, we observed the pregnancy time of female workers who wanted to give birth. Results ①The pregnancy rate of the first menstrual cycle among the 257 exposed women was 27.2%, the cumulative pregnancy rate in the first 3 months was 58.7%, and the cumulative pregnancy rate in 1 year was 93.7%, which were significantly lower than the control Group (35.8%, 69.1% and 97.0%, P values were 0.0181, 0.0040 and 0.0145, respectively); ② The pregnancy rate of women workers or both couples who were exposed to CS2 was low The pregnancy rate of CS2 women who did not contact with CS2 was significantly higher than that of the CS2 women (P = 0.024); CS2 female workers’ time of pregnancy was not significantly different from that of CS2 (r = 0.1198, P = 0.024) And contact time (r = 0.2799, P = 0.000) showed a positive correlation. Conclusion Female CS2 can prolong the time required for pregnancy and reduce fertility. Pregnancy time can be used as a primary screening index for female reproductive injury.