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目的 研究卡托普利抗实验性动脉粥样硬化的作用。方法 观察了正常对照、高脂对照及卡托普利三组鹌鹑 8周 ,分别采血测血液粘度、红细胞压积等各项指标 ,并光镜及电镜下观察其主动脉的病理变化。结果 卡托普利有良好抗动脉粥样硬化作用 ,可能是通过升高超氧化物歧化酶 (SOD)、6 -酮 -前列腺素F1α(6 ketoPGF1α) ,降低脂质过氧化物 (LPO)、血栓烷B2 (TXB2 )、TXB2 /6 ketoPGF1α及改善血液流变学参数来发挥作用。结论 卡托普利可能成为一种新的抗动脉粥样硬化的药物。
Objective To study the anti-experimental atherosclerosis effect of captopril. Methods The normal control group, high-fat control group and captopril three groups of quail for 8 weeks were observed blood viscosity, hematocrit and other indicators, and light microscopy and electron microscopy of aortic pathological changes. Results Captopril had a good anti - atherosclerosis effect, possibly by increasing superoxide dismutase (SOD), 6 - keto - prostaglandin F1α (6 ketoPGF1α), lowering lipid peroxide (LPO), thrombus Alkaloid B2 (TXB2), TXB2 / 6 ketoPGF1α and improving hemorheological parameters. Conclusion Captopril may become a new anti-atherosclerotic drug.