【摘 要】
：
AIM: To investigate the implication of angiogenin (ANG) in the neovascularizaton and growth of human gastric carcinoma (HGC).METHODS: ANG mRNA expression in HGC
【机 构】
：
Department of Physiology and Pathophysiology,Department of Pathology,Department of Biochemistry and
论文部分内容阅读
AIM: To investigate the implication of angiogenin (ANG) in the neovascularizaton and growth of human gastric carcinoma (HGC).METHODS: ANG mRNA expression in HGC specimens obtained by surgical resection from patients with HGC were examined by RT-PCR. ANG, Ki-67, VEGF protein expression and microvessel density (MVD) in HGC specimens were detected by immunohistochemistry. RESULTS: RT-PCR showed significantly higher ANG mRNA expression (0.482 ± 0.094) in HGC tissues than in the surrounding nontumorous tissues (0.276 ± 0.019, P = 0.03). MVD within tumorous tissues increased significantly with ANG mRNA expression (r = 0.380, P = 0.001) and ANG protein expression (P ＜ 0.01). The ANG expression levels of cancer tissues were positively correlated with VEGF (P ＜ 0.01) and the proliferation index of cancer cells (P ＜ 0.01).CONCLUSION: ANG is one of the neovascularization factors of HGC. ANG may work in coordination with VEGF, and promote the proliferation of HGC cells.
其他文献
AIM: To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vac4 gene influence the type of diseases in
Takayasu arteritis (TA) is a nonspecific granulomatous inflammatory arteriopathy of unknown cause that results in occlusive obliteration or less commonly aneury
AIM: Thioacetamide (TAA) has been used in studying liver fibrosis and cirrhosis, however, the mechanisms of TAA-induced apoptosis in liver are still unclear. Th
AIM: To explore the effects of interferon-α (IFN-α) application on peripheral circulating CD1α dendritic cells (DCs)in patients with chronic hepatitis B, and
Selective cyclooxygenase (COX)-2 inhibitors (coxibs)were developed as one of the anti-inflammatory drugs to avoid the various side effects of non-steroidal anti
Coronary artery fistula (CAF), an uncommon form of congenital heart disease, is characterized by abnormal communication between a coronary artery and a cardiac
AIM: To find out whether there are differences in attitudes about colorectal cancer (CRC) screening among gastrointestinal (GI) specialists and general practiti
Diverticular disease of the colon is primarily a disease of humans living in westernized and industrialized countries. Sixty percent of humans living in industr
The hormonal interactions among the systems throughout the body are not fully understood; many vague clinical symptoms may in fact be manifestations of underlyi
CO2属于环境友好型制冷剂,其跨临界循环非常适用于热泵系统.通过对自然工质物性和CO2污水源热泵专用活塞压缩机不可逆损失的研究,构建了带节流阀和带膨胀机的2种单级CO2污水