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牛磺酸是动物体内含量最丰富的自由氨基酸,有着广泛的生物学效应,对于维持和调节细胞正常功能具有重要生理意义。近年来发现牛磺酸对于心肌缺血-再灌注损伤具有非常有效的防治作用,但其作用机理尚不清楚。已知钙超载(calcium overload)是心肌缺血-再灌注损伤的主要发病环节之一.本工作在离体灌流大鼠心脏缺血-再灌注损伤模型上,观察牛磺酸对心肌组织钙含量和心肌对~(45)Ca摄取的影响,以探讨牛磺酸的细胞保护机制。
Taurine is the most abundant free amino acid in animals and has a wide range of biological effects. It plays an important physiological role in maintaining and regulating the normal function of cells. In recent years, taurine has been found to have a very effective preventive and therapeutic effect on myocardial ischemia-reperfusion injury, but its mechanism of action is not yet clear. It is known that calcium overload is one of the main pathogenesis of myocardial ischemia-reperfusion injury.In this study, we observed the effect of taurine on myocardial tissue calcium content And myocardial uptake of ~ (45) Ca, in order to explore the mechanism of taurine cell protection.