目的:研究米非司酮配伍米索前列醇序贯口服终止9～16周妊娠的临床效果,旨在寻找一种安全、有效、省时、经济的终止9～16周妊娠的新方法。方法:收集孕9～16周要求终止妊娠的无禁忌证的孕妇120例,分为两组:甲组9￣12周内妊娠62例;乙组12￣16周内妊娠58例。甲组第一天空腹口服米非司酮150mg,4小时后于阴道后穹隆置米索前列醇200#g,以后每隔4小时口服米索前列醇200#g,口服400mg后根据宫缩情况每4小时追加一次米索前列醇,不超过1200#g;乙组第一天空腹口服米非司酮150mg,24小时后于阴道后穹隆置米索前列醇200mg,以后操作同甲组;观察两组的流产成功率,胎儿及附属物排除时间,出血量,不良反应,并发症发生情况,并作统计学处理。结果:两组流产成功率分别为91.2%和93.2%差异无显著性,总成功率达92.6%。两组胎儿及附属物排除时间、出血量、不良反应,并发症发生率差异无显著性。结论:口服米非司酮配伍米索前列醇用于终止妊娠流产成功率高,并发症少,安全简便,省时,是终止9～16周妊娠的安全、有效的方法。口服给药操作方便,时间短,节省住院天数。口服药物不成功需行钳刮术时因宫颈已扩张,胎儿死亡可降低钳刮术并发症,减轻孕妇痛苦,缩短手术时间,减少出血量。药物流产后常规清宫。 OBJECTIVE: To study the clinical efficacy of mifepristone and misoprostol for the sequential oral administration of 9 to 16 weeks of gestation, aiming at finding a safe, effective, time-saving and economical new method to terminate the pregnancy of 9 to 16 weeks. Methods: A total of 120 pregnant women without contraindication who required termination of pregnancy from 9 to 16 weeks of gestation were divided into two groups: 62 cases of pregnancy in group A within 9 to 12 weeks and 58 cases of pregnancy in group B within 12 to 16 weeks. A group of the first day of fasting oral mifepristone 150mg, 4 hours after the vaginal posterior vaginal set misoprostol 200 # g, after every 4 hours oral misoprostol 200 # g, 400mg oral according to contractions Every 4 hours additional misoprostol, not more than 1200 # g; the first day of group B fasting oral mifepristone 150mg, 24 hours after the vaginal posterior dome misoprostol 200mg, after the operation with a group; observation Two groups of abortion success rate, fetal and appendix exclusion time, bleeding, adverse reactions, complications, and for statistical analysis. Results: The two groups of abortion success rates were 91.2% and 93.2%, respectively, with no significant difference, with a total success rate of 92.6%. Two groups of fetuses and appendages excluding time, bleeding, adverse reactions, the incidence of complications was no significant difference. Conclusion: The success rate of oral mifepristone and misoprostol for termination of pregnancy is high, the complication is less, the safety is simple and the time saving is the safe and effective method to terminate the pregnancy of 9 ~ 16 weeks. Oral administration easy operation, time is short, save days of hospitalization. Failure of oral medication required forceps curettage due to cervical expansion, fetal death can reduce the complications of forceps curettage, reduce the pain of pregnant women, shorten the operation time and reduce the amount of bleeding. After the medicine routine abortion.