目的　研究肝豆状核变性 (HLD)患者并发胆囊异常及其相关因素。方法　对 2 0 0例HLD患者行胆囊B超检查 ,详细记录相关病史、症状、体征及临床分型 ,并分析其间的关系。结果　 2 0 0例患者中 82例经B超检查发现胆囊异常 ( 4 1 0 0 % ) ,主要表现为胆囊壁增厚、胆囊增大、慢性胆囊炎或胆囊结石等。临床分析表明 82例胆囊异常中仅 17例有胆囊疾病症状 ;胆囊异常与年龄、性别无关 ,而与早期肝症状及临床分型有关。结论　HLD患者往往并发胆囊异常 ,以具有早期肝症状及肝 -脑型的患者更为多见 ,B超检查有益于胆囊异常的发现 Objective To study the patients with hepatolenticular degeneration (HLD) complicated by gallbladder abnormalities and its related factors. Methods 200 cases of HLD patients underwent gallbladder B-ultrasound, a detailed record of the relevant history, symptoms, signs and clinical classification, and analyze the relationship between them. Results Eighty-two cases of 82 patients were diagnosed as gallbladder abnormalities by B-mode ultrasound (4100%). The main manifestations were gallbladder wall thickening, gallbladder enlargement, chronic cholecystitis or gallstone. Clinical analysis showed that only 82 cases of gallbladder abnormalities in 17 cases of gallbladder disease symptoms; abnormal gallbladder age and sex has nothing to do, but with early liver symptoms and clinical classification. Conclusions Patients with HLD often have gallbladder abnormalities, which are more common in patients with early liver symptoms and liver-brain type. B-ultrasound is useful for the detection of gallbladder abnormalities