Truss core sandwich panels reinforced by carbon fibers were assembled with bonded laminate facesheets and carbon fiber reinforced truss cores. The top and bottom facesheets were interconnected with truss cores. Both ends of the truss cores were embedded into four layers of top and bottom facesheets. The mechanical properties of truss core sandwich panels were then investigated under out-of-plane and in-plane compression loadings to reveal the failure mechanisms of sandwich panels. Experimental results indicated that the mechanical behavior of sandwich structure under in-plane loading is dominated by the buckling and debonding of facesheets.