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目的评价血清丙氨酸氨基转移酶(ALT)与代谢综合征(MS)的相关性。方法研究500例我科住院患者及住院体检人群,入选对象均无酗酒史及慢性肝病史。检测腰围、血压、空腹血糖(FPG)、2 h血糖(2 h PG)、血清甘油三酯(TG)、血总胆固醇(TC)、空腹血浆胰岛素(Fins)、ALT。用HOMA-IR公式评估胰岛素抵抗(IR)程度。其中入选对象中MS组210例,正常对照组290例。结果 MS组ALT水平明显高于正常对照组(P<0.01)。MS患者ALT水平与HOMA-IR及MS的组分(体质量指数、血压、TG、TC和FPG)呈正相关。结论 MS患者血清ALT水平显著高于正常人群,其升高与体质量指数、FPG、TG、血压及HOMA-IR关系密切。ALT水平与其他MS指标相结合有利于正确评价MS的进展情况。
Objective To evaluate the relationship between serum alanine aminotransferase (ALT) and metabolic syndrome (MS). Methods 500 cases of inpatients and inpatients in our department were enrolled in this study. All the selected subjects had no history of alcoholism and chronic liver disease. Blood pressure, FPG, 2 h PG, TG, TC, Fins and ALT were measured. HOMA-IR formula was used to assess the degree of insulin resistance (IR). Among them, 210 cases were selected as MS group and 290 cases as normal control group. Results The level of ALT in MS group was significantly higher than that in normal control group (P <0.01). MS patients with ALT levels and HOMA-IR and MS components (body mass index, blood pressure, TG, TC and FPG) was positively correlated. Conclusion The level of serum ALT in MS patients is significantly higher than that in normal subjects. The elevated serum ALT levels are closely related to body mass index, FPG, TG, blood pressure and HOMA-IR. The combination of ALT levels with other MS measures can help to correctly assess the progress of MS.