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采用高碳酸性缺氧,窒息性缺氧,小鼠抗缺氧及耗氧量同步测定等方法,研究噻拉嗪的抗缺氧作用。结果表明噻拉嗓明显延长缺氧大鼠出现脑皮层电图(ECOG)平坦期时间及心电(ECG)消失时间。并延长小鼠心电消失时间。同时证实噻拉嗪有两种作用:(1)降低耗氧量;(2)提高对缺氧的耐受力。微量的噻拉嗪脑室内注射,对小鼠缺氧保护作用显著,并为咪唑克生阻断,提示上述作用与中枢α_2受体相关。
Using high carbon acid hypoxia, asphyxia hypoxia, anti-hypoxia and oxygen consumption in mice simultaneous determination of other methods to study the anti-hypoxia effect of thiazide. The results showed that thoracic sore significantly prolonged cortical ecstolic (ECOG) flat time and ECG disappearance time in hypoxic rats. And to extend the disappearance of the mouse ECG time. At the same time confirmed that thiazide has two effects: (1) reduce oxygen consumption; (2) to improve tolerance to hypoxia. Microinjection of intraventricular injection of thiazolidine significantly inhibits hypoxia in mice and blockade of imidazocin, suggesting that these effects are related to the central α_2 receptor.