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目的:优选强志怡神胶囊的大孔树脂纯化工艺。方法:以细叶远志皂苷、芍药苷、甘草酸、甘草苷的比吸附量和洗脱率为指标筛选大孔树脂型号。采用单因素试验考察上样液质量浓度、径高比、洗脱剂体积等因素对强志怡神胶囊大孔树脂纯化工艺的影响。结果:选用HPD-100型大孔树脂,最佳纯化工艺为上样液质量浓度0.1 g·m L-1,树脂-生药量(3∶1),树脂径高比1∶7.5,上样速度3 BV·h-1,加4 BV水洗除杂,继加70%乙醇5 BV洗脱,洗脱速度3 BV·h-1。细叶远志皂苷、芍药苷、甘草酸、甘草苷的转移率分别为78.55%,88.62%,82.47%,83.15%,得膏率7.52%,干燥时间0.5 h。结论:该工艺能有效去除远志、白芍、甘草水提液中的淀粉、糖类等杂质,所得纯化物易于制剂成型,可作为强志怡神胶囊的纯化工艺。
Objective: To optimize the Macroreticular resin purification technology of Qizhi Yishen Capsule. Methods: The macroporous resin models were screened with the specific absorption capacity and elution rate of Polygonatum sibiricum, paeoniflorin, glycyrrhizin and glycyrrhizin. Single factor test was used to investigate the effect of Qiangzhiyi Shen capsule macroporous resin purification process, such as the concentration of sample solution, the aspect ratio and the volume of eluent. Results: The best purification technology was HPD-100 macroporous resin. The optimum concentration was 0.1 g · m L-1, the resin-crude drug volume was 3:1, the diameter-diameter ratio of resin was 1: 7.5, 3 BV · h-1, plus 4 BV water wash impurity, followed by 70% ethanol 5 BV eluting rate of 3 BV · h-1. Proliferation of paeoniflorin, paeoniflorin, glycyrrhizin and glycyrrhizin were 78.55%, 88.62%, 82.47% and 83.15%, respectively, and the transfer rate was 7.52% and the drying time was 0.5 h. CONCLUSION: The process can effectively remove starch, sugar and other impurities from Polygala tenuifolia, Radix Paeoniae Alba and licorice water extract. The obtained purified product is easy to be formed into a preparation and can be used as a purification process of Qizhi Yishen Capsule.