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目的:观察中药配合心理干预治疗AS临床疗效及对焦虑、抑郁的影响。方法:将84例符合纳入标准的AS患者随机分为治疗组和对照组,治疗组给予舒肝强脊汤同时进行心理干预,对照组给予柳氮磺胺吡啶(SASP)口服,疗程为4周。治疗前后观察BASDAI、BASFI、ASAS20、BASDAI50、SAS、SDS。结果:治疗后2组BASDAI、BASFI评分均明显下降,差异有统计学意义(P<0.01);治疗前后BASDAI、BASFI评分差值比较,2组差异有统计学意义(P<0.01)。与对照组比较,治疗组ASAS20、BASDAI50明显改善,差异有统计学意义(P<0.01)。2组治疗前后SAS、SDS评分差值比较,差异有统计学意义(P<0.01)。结论:中药配合心理干预的临床疗效优于SASP,不仅改善AS患者临床症状,而且显著减轻患者的抑郁焦虑程度。
Objective: To observe the clinical efficacy of traditional Chinese medicine combined with psychological intervention on AS and its effect on anxiety and depression. Methods: Eighty-four AS patients who met the inclusion criteria were randomly divided into treatment group and control group. The treatment group received Shugan Qiangji Decoction and psychological intervention. The control group was given sulfasalazine (SASP) orally for 4 weeks. Before and after treatment, we observed BASDAI, BASFI, ASAS20, BASDAI50, SAS and SDS. Results: After treatment, BASDAI and BASFI scores decreased significantly in both groups (P <0.01). There was significant difference between BASDAI and BASFI scores before and after treatment (P <0.01). Compared with the control group, the treatment group ASAS20, BASDAI50 significantly improved, the difference was statistically significant (P <0.01). The differences of SAS and SDS scores before and after treatment in the two groups were statistically significant (P <0.01). Conclusion: The clinical curative effect of traditional Chinese medicine combined with psychological intervention is superior to SASP, not only improving the clinical symptoms of AS patients, but also significantly reducing the degree of depression and anxiety in patients.