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组织因子途径抑制物-2(TFPI-2)属于库尼(Kunitz)型丝氨酸蛋白酶抑制剂家族蛋白,是一种广谱的丝氨酸蛋白酶抑制物。大量研究表明,TFPI-2通过抑制和降解基质金属蛋白酶,抑制肿瘤新生血管生成,抑制TF-FVIIa复合物介导的信号转导途径以及诱导肿瘤细胞凋亡等机制调控某些恶性肿瘤细胞的侵袭和转移。就TFPI-2的分子生物学特点、与恶性肿瘤侵袭转移的关系,及其与妇科肿瘤关系的研究进展综述。
Tissue factor pathway inhibitor-2 (TFPI-2) belongs to the Kunitz family of serine protease inhibitor family of proteins and is a broad-spectrum serine protease inhibitor. A large number of studies have shown that TFPI-2 regulates the invasion of certain malignant tumor cells by inhibiting and degrading matrix metalloproteinases, inhibiting tumor angiogenesis, inhibiting TF-FVIIa complex-mediated signal transduction pathway and inducing tumor cell apoptosis And transfer. Molecular biology of TFPI-2, its relationship with invasion and metastasis of malignant tumors, and its relationship with gynecological tumors.