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本文观察了SHR和WKY及不同年龄SHR动脉血浆中TXA_2和PGI_2的稳定代谢产物TXB_2和6-Keto-PGF_(1α)的浓度及其比值变化。结果表明,SHR血浆中的TXB_2浓度显著高于WKY,对照组与实验组相比(207.1±59.8比1217.9±298.5P8/ml,P<0.001),而血浆中6-Keto-PGF_(1α)浓度,除高年龄组SHR外,其他各组均无明显改变;SHR各组血浆中6-Keto/TXB_2比值均显著低于WKY组,不同年龄组SHR血浆中TXB_2浓度相比,高年龄组明显高于低年龄组(2184.5±273.1比1290.6±284.4pg/ml,P<0.001),高年龄组血浆中6-Keto-PGF_(1α)浓度虽有升高,但6-Keto/TXB_2比值仍明显低于对照组(0.21±0.12比1.48±0.78,P<0.001)。这些变化可能与SHR高血压的持续发展有关。
In this paper, we observed the concentration of TXB_2 and 6-Keto-PGF_ (1α) in TXA_2 and PGI_2 of SHR and WKY and arterial plasma of SHR at different ages and their ratio changes. The results showed that the concentration of TXB_2 in SHR plasma was significantly higher than that in WKY group (207.1 ± 59.8 vs. 1217.9 ± 298.5P8 / ml, P <0.001), while the plasma concentration of 6-Keto-PGF_ (1α) , Except for the SHR in high age group, there was no significant change in other groups; the ratio of 6-Keto / TXB_2 in SHR groups was significantly lower than that in WKY group, TXB_2 in SHR plasma was significantly higher in different age groups In the low age group (2184.5 ± 273.1 vs 1290.6 ± 284.4 pg / ml, P <0.001), the 6-Keto-PGF 1α concentration was still significantly lower in the high-age group In the control group (0.21 ± 0.12 vs 1.48 ± 0.78, P <0.001). These changes may be related to the sustained development of SHR hypertension.