目的　探讨糖尿病患者高血压的发生机理。方法　应用新的荧光指示剂fura -2测定了 14例 2型糖尿病伴高血压患者及 2 5例不伴高血压者的淋巴细胞内胞浆游离钙浓度 ( [Ca2 + ]i) ,并分析其与胰岛素的关系。结果　①两组患者的 [Ca2 + ]i均高于正常对照组 ,而伴高血压组又高于不伴高血压组 ;②所有糖尿病患者 (伴或不伴高血压 )的血清基础胰岛素水平及糖负荷后胰岛素曲线下面积 (areaundercurve ,AUC)均与 [Ca2 + ]i呈显著正相关。结论　胰岛素及 [Ca2 + ]i的增多可能在糖尿病高血压的发生中起一定作用 Objective To investigate the pathogenesis of hypertension in diabetic patients. Methods The cytosolic free calcium concentration ([Ca2 +] i) in 14 patients with type 2 diabetes mellitus and 25 lymphocytes without hypertension was measured by a new fluorescent indicator fura -2 and analyzed Relationship with insulin. Results ① The levels of [Ca2 +] i in both groups were significantly higher than those in the control group, while those in the group with hypertension were higher than those in the group without hypertension. (2) Serum basal insulin levels in all patients with diabetes mellitus (without or with hypertension) The area under the curve of insulin load (AUC) had a significant positive correlation with [Ca2 +] i. Conclusion The increase of insulin and [Ca2 +] i may play a role in the development of diabetic hypertension