肿瘤血管生成(angiogenesis)是指肿瘤细胞诱导的微血管生长以及肿瘤中血液循环建立的过程。20世纪70年代初,Folkman首先提出“肿瘤生长和转移都依赖于新生血管的形成”的概念[1],并且得到大量实验结果的证实[2、3]。肝细胞癌(肝癌)是典型的多血管肿瘤,其组织学的一个显著特性是 Tumor angiogenesis refers to the process by which tumor cells induce the growth of microvessels and the establishment of blood circulation in the tumor. In the early 1970s, Folkman first proposed the concept of “tumor growth and metastasis are dependent on the formation of neovasculature” [1], and confirmed by a large number of experimental results [2,3]. Hepatocellular carcinoma (HCC) is a typical multi-vessel tumor and one of its salient features is