鼻咽癌首选放疗,尽管近年来影像诊断及放疗技术提高,局部晚期患者单纯放疗5年生存率仍不理想,失败的主要原因为局部复发及远处转移。近年来放化疗综合治疗成为局部晚期鼻咽癌研究热点,目前的主要模式有诱导化疗、同期放化疗、辅助化疗及不同序贯的组合。现综述已发表的Ⅲ期临床试验及Meta分析结果,以明确不同化疗序贯的价值和地位,并探讨目前放化疗结合研究新方向。 Nasopharyngeal carcinoma preferred radiotherapy, in spite of improved imaging diagnosis and radiotherapy in recent years, locally advanced radiotherapy 5-year survival rate is still not ideal, the main reason for the failure of local recurrence and distant metastasis. In recent years, radiotherapy and chemotherapy combined treatment has become a hot research topic for locally advanced nasopharyngeal carcinoma. At present, the main modes are induction chemotherapy, concurrent chemoradiotherapy, adjuvant chemotherapy and combination of different sequences. Now reviewed the published phase Ⅲ clinical trials and Meta analysis results to clarify the value of different chemotherapy regimens and status, and to explore the current new direction of combination of radiotherapy and chemotherapy.