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目的:测定甘草酸二铵的体内药物动力学参数。方法:高效液相色谱法测量大耳免静脉滴注试药后不同时间的血药浓度,利用药物动力学专用软件3P97进行数据计算分析。结果:发现甘草酸二铵在体内呈现典型的开放二室动力学模型特征。并得到了静脉滴注甘草酸二铵主要的药物动力学参数。结论:此方法简单、可靠、数据准确。
OBJECTIVE: To determine in vivo pharmacokinetic parameters of diammonium glycyrrhizinate. Methods: HPLC was used to measure the blood concentration at different times after the medicine was administered to the large auricle in rabbits. The data were analyzed by the software 3P97 of Pharmacokinetics. RESULTS: Diammonium glycyrrhizinate was found to exhibit a typical open-chamber two-compartment kinetic model in vivo. The main pharmacokinetic parameters of diammonium glycyrrhizinate were obtained. Conclusion: This method is simple, reliable, accurate data.