铜绿假单孢菌是一种重要的院内感染条件致病菌 ,具有先天的和后天获得的多重高度耐药性 ,一旦感染 ,临床治疗十分困难。铜绿假单孢菌的耐药机理十分复杂 ,除常见耐药机制外 ,很重要的就是其拥有可以外排多种药物的主动外排系统 ,使抗菌药物很难发挥应有作用。本文将从近年铜绿假单孢菌中各类外排泵的研究情况 ,特别是其中最重要的外排系统“MexAB -OprM”的分子结构模型、膜定位、该基因的表达与调控等方面的研究进展做一综述。 Pseudomonas aeruginosa is an important causative agent of nosocomial infections with multiple, highly resistant inherited and acquired. Once infected, clinical treatment is difficult. The mechanism of drug resistance of Pseudomonas aeruginosa is very complicated. In addition to the common mechanism of resistance, it is very important that it has an active efflux system that can drain a variety of drugs, making it difficult for antibacterials to play its due role. In this paper, the recent researches on various types of efflux pumps in Pseudomonas aeruginosa, especially the molecular structure model of the most important efflux system “MexAB -OprM”, membrane localization, the expression and regulation of the gene The research progress is reviewed.