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抗疟原虫环子孢子(CS)蛋白重复区的多克隆和单克隆抗体被动转移给小鼠和猴,能抵抗子孢子诱导的疟疾。以伯氏疟原虫蛋白重复区为主要结构的合成肽和重组蛋白疫苗在实验动物亦显示诱导产生保护性免疫。为此,作者设计了恶性疟原虫的CS蛋白疫苗:含有B细胞表位的CS蛋白重复区(R32)T辅助细胞表位的流感病毒A非结
Polyclonal and monoclonal antibodies against the antigenic region of the circumsporozoite antigen (CS) of the Plasmodium falium were passively transferred to mice and monkeys against sporozoite-induced malaria. Synthetic peptides and recombinant protein vaccines dominated by the P. berghei protein repeat are also shown to induce protective immunity in experimental animals. To this end, the authors designed a CS protein vaccine against Plasmodium falciparum: influenza A non-node containing the CS-cell repeats (R32) T helper epitopes of B-cell epitopes