论文部分内容阅读
用分子生物学方法动态观察ＨＦＲＳ患者外周血和单核细胞中在第３、５、７和１４病日检出ＨＦＲＳＶ抗原的同时，发现ＨＦＲＳ患者在第３～１４病日外周血单核细胞中亦可查到ＭＰ和ＮＰ，说明ＨＦＲＳＶ在其细胞内存留时间较长，并不断有病毒ＭＰ和ＮＰ表达，在早期ＭＰ表达较强者中大部分患者有典型５期经过或向重型发展；ＭＰ持续高表达者则病情重预后差。随着病程延长和机体产生中和抗体，病毒复制减少，ＭＰ和ＮＰ表达也随之减弱乃至消失。此外，轻型和重型病人血清抗体检测表明，血清特异性ＩｇＭ滴度的高低与病情的轻重关系密切而ＩｇＧ则与病情轻重无关。
Dynamic observation of HFRSV antigen in peripheral blood and mononuclear cells of HFRS patients by molecular biology method was also found on the 3rd, 5th, 7th and 14th day, and HFRS patients were found in the peripheral blood mononuclear cells MP and NP can also be found, indicating that HFRSV in their long-term retention of cells, and continue to have the virus MP and NP expression in the early MP expression of the strong majority of patients with typical stage 5 after heavy or heavy development; MP Persistent high expression of the disease after the poor prognosis. With prolonged course and the body to produce neutralizing antibodies, viral replication decreased, MP and NP expression also will be reduced or even disappear. In addition, light and heavy patient serum antibody tests showed that the level of serum-specific IgM titer closely related to the severity of the disease and IgG has nothing to do with the severity of illness.